Department of Biochemistry and Biophysics. SciLifeLab (SciLifeLab) is a national center for molecular life sciences with a focus on research in health and the environment. The center combines leading technical expertise with advanced knowledge in translational medicine and molecular life sciences. SciLifeLab is a national resource operated by Karolinska Institutet, KTH, Stockholm University, and Uppsala University. The center collaborates with several other universities.
Administratively, the position will be placed at the Department of Biochemistry and Biophysics, Stockholm University. For more information about our activities, see our website: www.dbb.su.se
Project Description
A postdoctoral position is available in Emil Marklund's research laboratory, located at the SciLifeLab campus Solna in Stockholm. In the Marklund lab (marklundlab.com), we investigate how the sequence of biological macromolecules directs recognition, binding, and dynamic structure. We combine high-throughput measurements of molecular binding with simulations and quantitative modeling to gain a physical understanding of life at the molecular level.
We are now recruiting a postdoctoral researcher who wants to use and develop state-of-the-art methods to study binding and dynamic structure of DNA, RNA, and proteins. Scientific questions in projects may include, for example, studying specificity in transcription factor-DNA binding, discovering protein-protein interactions, or enzyme optimization.
Responsibilities
The selected candidate will use and develop methods within one or more of the following categories:
Optical techniques, fluorescence microscopy, image analysis: Development of microscopy, fluidics, and data analysis pipelines used to measure and quantify binding in high-throughput. Examples of suitable backgrounds: Optical engineering, hardware-software integration, image analysis.
Sequence library design, molecular cloning, and protein purification: Design and prepare molecular sequence variants for which binding will be studied in high-throughput. Examples of suitable backgrounds: Molecular biology, protein engineering, biochemistry.
Build quantitative models: Use high-throughput binding data to build sequence-dependent predictive deep learning models and physical mechanistic models (thermodynamic and kinetic models, etc.). Examples of suitable backgrounds: Machine learning, programming, mathematics, physics.
You will participate in shaping the project according to the lab's overall objectives and will be responsible for its implementation. We are an interdisciplinary lab and you will be encouraged to collaborate with other researchers in the team.
Qualifications
To be eligible for employment as a postdoctoral researcher, a doctoral degree or a foreign degree assessed as equivalent to a relevant doctoral degree is required. The degree must be completed by the time the employment decision is made.
Evaluation Criteria
It is meritorious if the doctoral degree or equivalent was completed no more than three years before the final application deadline. If there are special circumstances, an earlier completed degree may also be considered meritorious. Special circumstances include leave due to illness, parental leave, assignments of trust within trade union organizations, service in total defense, or other similar circumstances, as well as clinical service or service/assignments relevant to the subject area.
In the appointment, particular emphasis will be placed on scientific excellence within the categories listed above, with particular emphasis on expertise in biophysics, molecular biology, biochemistry, optical techniques, and deep machine learning.
We would also like you to have these qualities:
A curious and driven personality with a passion for basic research and/or method development.
Good ability to work in a team.
Strong publications or other evidence of scientific ability and maturity.
Excellent communication skills in English.
Experience solving complex scientific problems or method development within at least one of the categories mentioned above.
About the Position
The position is full-time and is permanent, but for a minimum of two years and a maximum of three years, with the possibility of extension if there are special reasons. Start date according to agreement.
What We Offer
With us, you will experience the dynamics of the interaction between higher education and research that makes Stockholm University an exciting and creative environment. You will work in an international environment and receive favorable conditions.
Stockholm University is committed to being a workplace free from discrimination that provides equal rights and opportunities for all.
Contact
Information about the position is provided by Assistant Professor Emil Marklund, [email protected].
Application
You apply for the position through Stockholm University's recruitment system. Attach a cover letter and CV along with any attachments requested in the application form. As an applicant, you are responsible for ensuring that your application is complete and submitted to the university by the final application deadline.
Instructions for applicants can be found on the website: applying for a position.
Stockholm University contributes to the development of a sustainable democratic society through knowledge, enlightenment, and truth-seeking.Department of Biochemistry and Biophysics. SciLifeLab (SciLifeLab) is a national center for molecular life sciences with a focus on research in health and the environment. The center combines leading technical expertise with advanced knowledge in translational medicine and molecular life sciences. SciLifeLab is a national resource operated by Karolinska Institutet, KTH, Stockholm University, and Uppsala University. The center collaborates with several other universities.
Administratively, the position will be placed at the Department of Biochemistry and Biophysics, Stockholm University. For…