Researcher

Gothenburg University meets societal challenges with diverse knowledge. 58,000 students and 6,800 employees make the university a large and inspiring workplace. Strong research and attractive educational programs attract researchers and students from around the world. With new knowledge and new perspectives, Gothenburg University contributes to a better future. The Department of Medicine, Division of Molecular and Clinical Medicine, conducts translational research primarily focused on metabolism, diabetes, obesity, and cardiovascular disease with the aim of improving health and healthcare in society. The overarching goal is to create an excellent translational research environment of very high international standard. The Romeo laboratory studies the biological and genetic mechanisms behind metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to liver fibrosis and cirrhosis. Our research combines human genetics with experimental models to identify disease mechanisms and therapeutic targets. We use state-of-the-art cell culture systems, liver organoids, and molecular biological methods to investigate signaling pathways involved in liver injury and fibrosis. Responsibilities The successful candidate will participate in an experimental research project investigating genes involved in susceptibility to liver fibrosis and cirrhosis. The responsibilities include establishment and maintenance of spheroid and organoid cultures from hepatocyte cell lines and primary human hepatocytes as well as generation and maintenance of stable mammalian cell lines. The work also encompasses the use of molecular biological methods, including DNA and RNA isolation, DNA cloning, transfection, PCR, protein expression analyses, and RNA expression profiling. Further, the candidate will perform biochemical analyses such as immunoblotting (Western blot), immunoprecipitation, subcellular fractionation, and siRNA-mediated gene silencing. The project includes metabolic flux experiments with radioactive tracers, as well as immunocytochemistry and in situ hybridization experiments. Analysis of genetic and genomic datasets will be conducted using R- and Linux-based computational tools. The work also includes documentation, analysis, and presentation of experimental results as well as active participation in regular laboratory meetings and scientific discussions. The position offers an opportunity to gain practical experience in translational liver research and experimental disease modeling. Qualifications The applicant should have a background in biomedical sciences, molecular biology, biotechnology, cell biology, or another relevant life science discipline. Prior experience with organoid or spheroid culture or alternatively liver biology is required, as is practical experience with molecular biological work. Proficiency in spoken and written English is also necessary for the position. It is advantageous to have experience with omics analysis as well as work with mammalian cell culture, including spheroids and/or organoids, and generation of stable cell lines. Experience with molecular biological techniques such as DNA and RNA extraction, cloning, PCR, transfection, and gene expression analysis is also meriting. Further, experience with biochemical methods, for example Western blotting, immunoprecipitation, and immunocytochemistry, is considered an advantage. Knowledge of RNA interference (siRNA) as well as experience analyzing biological data using R- and/or Linux-based environments is also meriting. Previous experience with liver biology, metabolism, or experimental disease models will be valued positively. Great weight will be placed on personal suitability. The successful candidate should be motivated and well-organized, able to work both independently and as part of a research team, and have a genuine interest in experimental biomedical research. Employment Employment type: Fixed-term position Scope: 100% Location: Department of Medicine, Gothenburg. Start date: By agreement; employment runs through December 31, 2026. Contact information for the position Stefano Romeo Professor/Specialist Physician 0768-67 26 34 [email protected] Malin Levin Department Head [email protected] Trade union representatives Trade union representatives at Gothenburg University can be found here: https://www.gu.se/jobba-hos-oss/sa-blir-du-en-av-oss#kollektivavtal-och-fackliga-foretradare Application You apply for the position via Gothenburg University's recruitment portal by registering your application electronically through the website: https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar. As an applicant, you are responsible for ensuring that your application is complete in accordance with the job posting and that it is submitted to the university by the final application deadline. A certificate of doctorate must be attached to the application. Application deadline: 2026-09-01 The university actively works for an equal working environment and values the qualities that diversity brings to its operations. The university applies individual salary setting. According to the regulations of the Swedish National Archives, the university is obligated to retain application materials for two years after the appointment decision. If you as an applicant specifically request that your materials be returned, they will be sent back after the two-year period has elapsed; otherwise they will be discarded. To staffing and recruitment companies and to you as a job advertisement seller: Gothenburg University uses a contracted advertising agency in connection with recruitment of personnel. We politely but firmly decline direct contact from staffing and recruitment companies as well as sellers of job advertisements.

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